Public and Independent Research Initiatives

This project focuses on developing a library of MOF-based nanocarriers specifically designed for delivering CRISPR/Cas9 systems to neuronal cells to target and suppress mutant huntingtin (HTT) gene expression. By systematically mapping various MOF structures and their efficiency in crossing the blood-brain barrier and achieving precise gene editing, the aim is to create a comprehensive resource for advancing therapeutic strategies for Huntington’s disease.

This project focuses on designing a MOF-based electrochemical biosensor capable of detecting dopamine alongside emerging biomarkers such as alpha-synuclein aggregates. By integrating the analysis of these critical indicators, the biosensor aims to provide a comprehensive tool for the early diagnosis and monitoring of Parkinson’s disease progression.

This project focuses on developing porous nanomaterials, including MOFs, as nanocarriers for the precise delivery of CRISPR/Cas9 to hepatic stellate cells, the primary mediators of liver fibrosis. By selectively targeting these cells, the aim is to explore gene-editing strategies that could reverse fibrosis progression and improve liver function in chronic liver disease.

This project investigates the use of MOF and MXene-based nanocarriers to deliver a combination of chemotherapy agents and targeted therapeutics specifically to triple-negative breast cancer cells. By encapsulating dual drugs within these porous materials, the goal is to enhance therapeutic efficacy while minimizing side effects through targeted delivery and controlled release.

This project aims to develop a wearable biosensor utilizing Zr-based metal-organic frameworks (MOFs) combined with aptamers to detect early biomarkers of neuroinflammation in Alzheimer's disease. The sensor will enable real-time, non-invasive monitoring, offering a promising approach for early diagnosis and tracking disease progression in Alzheimer's patients.

This project focuses on the design and synthesis of innovative metal-organic frameworks (MOFs) with highly tunable porosity and surface functionalities to create next-generation green biomaterials. By investigating the intricate relationship between structural parameters such as pore architecture, metal-ligand interactions, and surface reactivity, the goal is to develop MOFs with enhanced biodegradability, sustainability, and catalytic properties, driving transformative applications in environmental remediation, sustainable packaging, and energy-efficient systems.